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Publications

  • Kumar S., Valansi C., Haile M.T., Li X., Flyak K., Dwivedy A. et al. Malaria parasites utilize two essential plasma membrane fusogens for gamete fertilization. Cellular and Molecular Life Sciences (2022). Link

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  • ​Chauhan N., Xiong Y., Ren S., Dwivedy A. et al. Net-Shaped DNA Nanostructures Designed for Rapid/Sensitive Detection and Potential Inhibition of the SARS-CoV-2 Virus. Journal of American Chemical Society (2022). Link​

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  • Dwivedy A. et al. Characterization of the NiRAN domain from RNA-dependent RNA polymerase provides insights into a potential therapeutic target against SARS-CoV-2. Plos Computational Biology (2021). Link

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  • Mariadasse A., Rajmichael R., Dwivedy A. et al. Characterization of putative transcriptional regulator (PH0140) and its distal homologue. Cellular Signalling (2021). Link

 

  • Kumar D., Jha B., Bhatia I., Ashraf A., Dwivedy A. et al. Characterization of a triazole scaffold compound as an inhibitor of Mycobacterium tuberculosis Imidazoleglycerol‐phosphate dehydratase. Proteins: Structure, Function, and Bioinformatics (2021). Link

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  • Dwivedy A. et al. De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation. Communications Biology (2021). Link​​

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  • Dwivedy A. et al. Molecular basis of the logical evolution of the novel coronavirus SARS-CoV-2: A comparative analysis. BioRxiv (2020). Link

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  • Verma S., Dwivedy A. et al. Computational prediction and validation of miRNAs encoded by SARS-CoV-2 genome and identification of their putative host targets. BioRxiv (2020). Link

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  • Dwivedy A. et al. Prediction of Small Molecule Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus-2 RNA-dependent RNA Polymerase. ACS Omega (2020). Link

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  • Dwivedy A. et al. Serendipitous crystallization and structure determination of bacterioferritin (Bfr) from Achromobacter. Acta Crystallographica Section F (2018). Link

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  • Jha B., Kumar D., Sharma A., Dwivedy A. et al. Identification and structural characterization of a histidinol phosphate phosphatase from Mycobacterium tuberculosis. Journal of Biological Chemistry (2018). Link

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  • Singh K. H., Jha B., Dwivedy A. et al. Characterization of a secretory hydrolase from Mycobacterium tuberculosis sheds critical insight into host lipid utilization by M. tuberculosis. Journal of Biological Chemistry (2017). Link

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  • Dwivedy A. and Aich P. Importance of innate mucosal immunity and the promises it holds. International Journal of General Medicine (2011). Link

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Software & Languages

Cytoscape

Genespring

Pymol

AutoDock

UCSF Chimera

CCP4

Coot

MEGA

Graphpad Prism

SigmaPlot

Orange

Laboratory Expertise

Bacterial and Tissue culture

Transcriptomics

Proteomics

Biosafety Level-3

Protein biochemistry

Protein crystallography

Animal Handling

Focal animal sampling

Projects

ONGOING

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  • Assessing the anti-cancer efficacy of biomarker targeted DNA aptamer-nanostructure complex in AML models (April 2021-, UIUC).

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  • Developing in silico methods for predicting aptamer-protein interactions (February 2021-, UIUC).

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  • Developing an efficient and cost effective bacterial system for large scale production of DNA nanostructures (December 2020-, UIUC).

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  • Developing aptamers targeting prostate cancer derived bone metastases (December 2020-, UIUC).​

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PAST

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  • Functional characterization and design of small molecule inhibitors against Nsp12 (RNA-dependent RNA polymerase) from Severe Acute Respiratory Syndrome Coronavirus-2. (February 2020- July 2021, NII, New Delhi)

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  • Determining the role of histidine biosynthetic pathway in the pathogenesis of Mycobacterium tuberculosis. (January 2016- January 2020, NII, New Delhi)

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  • Deciphering the structure-function relationships of Histidinol dehydrogenase from Mycobacterium tuberculosis. (January 2014- July 2016, NII, New Delhi)

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  • Structural characterization of a serendipitously crystallized bacterioferritin  from Achromobacter DH1f. (February 2017- April 2018, NII, New Delhi)

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  • Functional characterization of a novel secretory hydrolase from Mycobacterium tuberculosis. (November 2015- June 2017, NII, New Delhi)

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  • Effects of probiotic treatment on human & mouse macrophages: A comparative genomic study. (January 2010- May 2012, NISER, Bhubaneswar)

 

  • Subjective Assessment of personality dimensions in bonnet macaques in wild. (May 2010- September 2010, NIAS, Bangalore; NISER, Bhubaneswar)

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